ZD 1839
Iressa
CAS: 184475-35-2
Molecular Formula: C22H24ClFN4O3
ZD 1839 - Names and Identifiers
| Name | Iressa |
| Synonyms | Iressa IRESSA ZD 1839 GEFITINIB AKOS 91371 Gefitinib Base Gefitinib(TINIBS) Gefitinib, Iressa, ZD1839 GEFITINIB RELATED COMPOUND n-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]- N-(3-Chlor-4-fluorophenyl)-7-[methoxy-6-[(3-morpholin-4-yl)propoxyl]-quinazolin-4-yl]amine Gefitinib N-(3-Chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine N-(3-Chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine Gefitinib |
| CAS | 184475-35-2 |
| EINECS | 643-034-7 |
| InChI | InChI=1/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27) |
ZD 1839 - Physico-chemical Properties
| Molecular Formula | C22H24ClFN4O3 |
| Molar Mass | 446.9 |
| Density | 1.322±0.06 g/cm3(Predicted) |
| Melting Point | 119-1200C |
| Boling Point | 586.8±50.0 °C(Predicted) |
| Flash Point | 308.659°C |
| Solubility | Soluble in DMSO (89 mg/ml at 25 °C), methanol (20 mg/ml), ethanol (4 mg/ml at 25 °C) |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White to beige powder |
| Color | white to beige |
| pKa | 7.00±0.10(Predicted) |
| Storage Condition | room temp |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| Refractive Index | 1.621 |
| Use | An EGFR-tyrosine kinase inhibitor |
ZD 1839 - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29349990 |
ZD 1839 - Reference
| Reference Show more | 1. Lv Xin, Zhou Linshui, Chen Ruilin, et al. Effect of shRNA Interference TTF-1 Gene on EGFR-TKI Sensitivity and Epithelial Mesenchymal Differentiation of Lung Adenocarcinoma Cells [J]. Zhejiang Medical 2019 v.41(22):28-32 108. 2. Chen Zhi, Yu Jiandong, Tang Chaoyuan, et al. Effect of Elemene Injection on Kinematic Transfer of Gefitinib in PC-9/GR Cells [J]. Chinese Patent Medicine, 2018, 40(002):284-290. 3. Lu Xin, Zhu Yuanhong, Zhou Linshui, Wang Zhen, Liu Zhengzhong. Intervention of ethanol extract of Hedyotis diffusa combined with gefitinib on TGF-β_1-induced epithelial mesenchymal transition of lung adenocarcinoma cell line H358 [J]. Chinese modern applied pharmacy, 2016,33(02):154-158. 4. Yanqiu, et al. "Comparative two-dimensional HepG2 and L02/ cell membrane chromatography/ C18/ time-of-flight mass spectrometry for screening selective anti-hepatoma components from Scutellariae Radix. "Journal of pharmaceutical and biomedical analysis 164 5. Lin, Qing, et al. "Design of gefitinib-loaded poly (l-lactic acid) microspheres via a supercritical anti-solvent process for dry powder inhalation." International journal of pharmaceutics 532.1 (2017): 573-580.https://doi.org/10.1016/j.ijpharm. 2017.09.051 6. Gu, Yanqiu, et al. "Development of 3-mercaptopropyltrimethoxysilane (MPTS)-modified bone marrow mononuclear cell membrane chromatography for screening anti-osteoporosis components from Scutellariae Radix." Acta Pharmaceutica Sinica B 10.10 (2020): 1856-186 7. [IF=3.935] Yanqiu Gu et al."Comparative two-dimensional HepG2 and L02/ cell membrane chromatography/ C18/ time-of-flight mass spectrometry for screening selective anti-hepatoma components from Scutellariae Radix."J Pharmaceut Biomed. 2019 Feb;164:550 8. [IF=11.413] Yanqiu Gu et al."Development of 3-mercaptopropyltrimethoxysilane (MPTS)-modified bone marrow mononuclear cell membrane chromatography for screening anti-osteoporosis components from Scutellariae Radix."Acta Pharm Sin B. 2020 Oct;10:1856 9. [IF=4.759] Zhihua Song et al."Synthesis and evaluation of fosfomycin group end-capped packing materials for hydrophilic interaction liquid chromatography."J Chromatogr A. 2021 Oct;1656:462529 10. [IF=4.207] Jianghua Ding et al."LPCAT1 promotes gefitinib resistance via upregulation of the EGFR/PI3K/AKT signaling pathway in lung adenocarcinoma."J Cancer. 2022; 13(6): 1837-1847 11. [IF=5.34] Hai-Qiao Wang et al."Schisandrin B targets cannabinoid 2 receptor in Kupffer cell to ameliorate CCl4-induced liver fibrosis by suppressing NF-κB and p38 MAPK pathway."Phytomedicine. 2022 Apr;98:153960 |
ZD 1839 - Nature
Open Data Verified Data
recrystallized from toluene, melting point 119-120 °c.
Last Update：2024-01-02 23:10:35
ZD 1839 - Preparation Method
Open Data Verified Data
4-(3 '-chloro-4'-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline, 3-morpholinopropyl chloride, potassium carbonate dissolved in dimethylformamide, the reaction was stirred. Then add 3 morpholino propyl chloride, stir, filter, filtrate is concentrated, the material obtained by column chromatography, with 4:1 acetic acid ethanol methanol elution, the obtained solid was recrystallized from toluene, and the product was obtained.
Last Update：2022-01-01 09:09:21
ZD 1839 - Use
Open Data Verified Data
developed by AstraZeneca, Switzerland, was first launched in Japan in 2002. Surface growth factor receptor, tyrosine kinase inhibitor. For the treatment of non-stem cell lung cancer. But the side effect is bigger.
Last Update：2022-01-01 09:09:22
Supplier List
Multiple SpecificationsSpot supply
Product Name: Gefitinib Visit Supplier Webpage Request for quotationCAS: 184475-35-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Multiple SpecificationsSpot supply
Product Name: Gefitinib Visit Supplier Webpage Request for quotationCAS: 184475-35-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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